Potential for Offspring with Varicocele and Pcos

Authors

  • Sayyidah Auliyaur Rohmah Natural Sciences Tadris Study Program, Tarbiyah Faculty, Universitas Islam Kediri
  • Anisa Wulandari Natural Sciences Tadris Study Program, Tarbiyah Faculty, Universitas Islam Kediri, East Java, Indonesia
  • Farisa Aina Fahma Natural Sciences Tadris Study Program, Tarbiyah Faculty, Universitas Islam Kediri, East Java, Indonesia
  • Abdul Rois Murthado Natural Sciences Tadris Study Program, Tarbiyah Faculty, Universitas Islam Kediri, East Java, Indonesia

DOI:

https://doi.org/10.56778/rjslr.v2i2.289

Keywords:

Infertility, varicocele, Polycystic Ovary Syndrome (PCOS), sperm quality, androgen levels, treatment.

Abstract

Infertility affects a significant portion of couples worldwide, with 30% of cases attributed to male factors, 30% to female factors, 30% to both partners, and 10% to unknown causes. This study focuses on two common causes of infertility: varicocele in men and Polycystic Ovary Syndrome (PCOS) in women. Varicocele, characterized by the enlargement of veins within the scrotum, disrupts spermatogenesis by increasing testicular temperature, leading to poor sperm quality. PCOS, affecting 5-10% of women of reproductive age, is marked by excessive androgen levels, irregular menstruation, and obesity, significantly raising the risk of infertility. Through case studies and literature review, this research highlights the potential for individuals with varicocele or PCOS to achieve pregnancy with appropriate treatment. The study aims to explore the specific examination and treatment processes required for these conditions and to provide insights into improving fertility outcomes for affected individuals.

References

Agenor, A., & Bhattacharya, S. (2015). Infertility and Miscarriage: Common Pathways in Manifestation and Management. Women’s Health, 11(4), 527–541. https://doi.org/10.2217/WHE.15.19

Akbar, A. (2020). Gambaran Faktor Penyebab Infertilitas Pria Di Indonesia: Meta Analisis. JURNAL PANDU HUSADA, 1(2), Article 2. https://doi.org/10.30596/jph.v1i2.4433

Armijo-Sánchez, A., Benítez Castillo, N., García-Vidal, E., Luna Chadid, M., Salvador Ballada, C., Valls Ricart, G., & Torres Pellens, V. (2024). Treatment With a Patented 3.6:1 Myo-Inositol to D-chiro-Inositol Ratio, Antioxidants, Vitamins and Minerals Food Supplement in Women With a History of Assisted Reproductive Technique (ART) Failures: A Series of Case Reports. Clinical Medicine Insights: Case Reports, 17, 11795476241242265. https://doi.org/10.1177/11795476241242265

Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., & Zuccotti, G. (2021). Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility. Nutrients, 13(6), 1848. https://doi.org/10.3390/nu13061848

Esteves, S. C., Gosálvez, J., López-Fernández, C., Núñez-Calonge, R., Caballero, P., Agarwal, A., Fernández, J. L., Esteves, S. C., Gosálvez, J., López-Fernández, C., Núñez-Calonge, R., Caballero, P., Agarwal, A., & Fernández, J. L. (2015). Diagnostic accuracy of sperm DNA degradation index (DDSi) as a potential noninvasive biomarker to identify men with varicocele-associated infertility. International Urology and Nephrology, 47(9), Article 9. https://doi.org/10.1007/S11255-015-1053-6

Franco, A., Proietti, F., Palombi, V., Savarese, G., Guidotti, M., Leonardo, C., Ferro, F., Manna, C., & Franco, G. (2023). Varicocele: To Treat or Not to Treat? Journal of Clinical Medicine, 12(12), 4062. https://doi.org/10.3390/jcm12124062

Kavoussi, P., Birowo, P., Saleh, R., Shah, R., & Agarwal, A. (2024). Varicocele and male infertility conundrum: Making sense of a never-ending story for the busy clinician. Arab Journal of Urology, 22(1), 1–5. https://doi.org/10.1080/20905998.2023.2291628

Khan, M. J., Ullah, A., & Basit, S. (2019). Genetic Basis of Polycystic Ovary Syndrome (PCOS): Current Perspectives. The Application of Clinical Genetics, Volume 12, 249–260. https://doi.org/10.2147/TACG.S200341

Kite, C., Lahart, I. M., Afzal, I., Broom, D. R., Randeva, H., Kyrou, I., & Brown, J. E. (2019). Exercise, or exercise and diet for the management of polycystic ovary syndrome: A systematic review and meta-analysis. Systematic Reviews, 8(1), 51. https://doi.org/10.1186/s13643-019-0962-3

Kotlyar, A. M., & Seifer, D. B. (2023). Women with PCOS who undergo IVF: A comprehensive review of therapeutic strategies for successful outcomes. Reproductive Biology and Endocrinology, 21(1), 70. https://doi.org/10.1186/s12958-023-01120-7

Love, J., McKenzie, J., Nikokavoura, E. A., Broom, I., Rolland, C., & Johnston, K. (2016). The experiences of women with polycystic ovary syndrome on a very low-calorie diet. International Journal of Women’s Health, Volume 8, 299–310. https://doi.org/10.2147/IJWH.S100385

Namita, J., Sonia, M., & Ved, P. (2022). Impact of various PCOS phenotypes on oocyte competence in an ART cycle. Clinical Journal of Obstetrics and Gynecology, 5(2), 067–071. https://doi.org/10.29328/journal.cjog.1001110

Pasqualotto, F. F., Lucon, A. M., Hallak, J., Goes, P. M., Saldanha, L. B., & Arap, S. (2003). Induction of spermatogenesis in azoospermic men after varicocele repair. Human Reproduction, 18(1), 108–112. https://doi.org/10.1093/humrep/deg032

Patel, S. (2018). Polycystic ovary syndrome (PCOS), is an inflammatory, systemic, lifestyle endocrinopathy. The Journal of Steroid Biochemistry and Molecular Biology, 182, 27–36. https://doi.org/10.1016/j.jsbmb.2018.04.008

Samardzic, T., Soucie, K., Schramer, K., & Katzman, R. (2021). “I didn’t feel normal”: Young Canadian women’s experiences with polycystic ovary syndrome. Feminism & Psychology, 31(4), 571–590. https://doi.org/10.1177/09593535211030748

Simon, V., Peigné, M., & Dewailly, D. (2023). The Psychosocial Impact of Polycystic Ovary Syndrome. Reproductive Medicine, 4(1), 57–64. https://doi.org/10.3390/reprodmed4010007

Smith, R., Kaune, H., Parodi, D., Madariaga, M., Rios, R., Morales, I., & Castro, A. (2006). Increased sperm DNA damage in patients with varicocele: Relationship with seminal oxidative stress. Human Reproduction (Oxford, England), 21(4), 986–993. https://doi.org/10.1093/humrep/dei429

Tan, R. Y., Grigg, J., & Kulkarni, J. (2018). Borderline personality disorder and polycystic ovary syndrome: A review of the literature. Australian & New Zealand Journal of Psychiatry, 52(2), 117–128. https://doi.org/10.1177/0004867417730650

Tatem, A. J., & Brannigan, R. E. (2017). The role of microsurgical varicocelectomy in treating male infertility. Translational Andrology and Urology, 6(4), 722–729. https://doi.org/10.21037/tau.2017.07.16

Ulhe, S. M., More, D., & Wanjari, M. (2024). Implications of Human Chorionic Gonadotropin (hCG) Therapy in a Varicocele Patient and Its Effect on In Vitro Fertilization (IVF) Outcome. Cureus, 16(2), e54893. https://doi.org/10.7759/cureus.54893

Valentino, M., Bertolotto, M., Derchi, L., & Pavlica, P. (2014). Children and adults varicocele: Diagnostic issues and therapeutical strategies. Journal of Ultrasound, 17(3), 185–193. https://doi.org/10.1007/s40477-014-0088-3

Veronika, I. L., I, I., & Ginting, R. I. (2022). Penerapan Metode Teorema Bayer Pada Sistem Pakar Dalam Mendiagnosa Penyakit Varikokel Pada Pria. Jurnal Cyber Tech, 2(10), Article 10. https://doi.org/10.53513/jct.v2i10.727

Wang, J., Yin, T., & Liu, S. (2023). Dysregulation of immune response in PCOS organ system. Frontiers in Immunology, 14, 1169232. https://doi.org/10.3389/fimmu.2023.1169232

Wasilewski, T., Łukaszewicz-Zając, M., Wasilewska, J., & Mroczko, B. (2020). Biochemistry of infertility. Clinica Chimica Acta, 508, 185–190. https://doi.org/10.1016/j.cca.2020.05.039

Will, M. A., Swain, J., Fode, M., Sonksen, J., Christman, G. M., & Ohl, D. (2011). The great debate: Varicocele treatment and impact on fertility. Fertility and Sterility, 95(3), 841–852. https://doi.org/10.1016/j.fertnstert.2011.01.002

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Published

2024-08-14

How to Cite

Sayyidah Auliyaur Rohmah, Anisa WULANDARI, Farisa Aina FAHMA, & Abdul Rois MURTADHO. (2024). Potential for Offspring with Varicocele and Pcos. RADINKA JOURNAL OF SCIENCE AND SYSTEMATIC LITERATURE REVIEW, 2(2), 324–330. https://doi.org/10.56778/rjslr.v2i2.289