The Impact of Probiotics Co-administration with Antibiotics on Health

Authors

  • Sreedeep Dey Department of Microbiology, Vijaygarh Jyotish Ray College, affiliated to The University of Calcutta https://orcid.org/0009-0006-5734-9483
  • Sreejita Das Department of Microbiology, Vijaygarh Jyotish Ray College, affiliated to The University of Calcutta, Kolkata, India.

DOI:

https://doi.org/10.56778/rjhs.v1i4.237

Keywords:

Probiotics antibiotics gut microbiota Antibiotic-associated diarrhea (AAD) immune modulation microbiome dysbiosis gut barrier function

Abstract

Antibiotics have updated modern medicinal practices by improving outcomes in infectious diseases. The broad-spectrum action of antibiotics can cause disruption in the balance of beneficial gut bacteria that eventually leads to adverse effects such as antibiotic-associated diarrhea (AAD) and an increased susceptibility to sudden infections. When probiotics, or live microorganisms, are administered in proper amounts, they can benefit our health. Using probiotics is a potential solution to mitigate these adverse effects. This review aims to provide a comprehensive analysis of the impact of probiotics co-administered with antibiotics on various aspects of health, including the prevention of AAD, modulation of gut microbiota, and enhancement of immune function. This research uses a literature review method, namely a series of activities related to collection methods of library data. the co-administration of probiotics with antibiotics represents a promising approach to mitigating the adverse effects of antibiotic therapy on gut health and overall well-being. Additionally, the potential mechanisms underlying these effects and highlighting the challenges and future directions in this field have also been discussed.

References

Abouelela, M. E., & Helmy, Y. A. (2024). Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives. Microorganisms, 12(3), 430. https://doi.org/10.3390/microorganisms12030430

Al-Fakhrany, O. M., & Elekhnawy, E. (2024). Next-generation probiotics: The upcoming biotherapeutics. Molecular Biology Reports, 51(1), 505. https://doi.org/10.1007/s11033-024-09398-5

Chang, C., & Lin, H. (2016). Dysbiosis in gastrointestinal disorders. Best Practice & Research Clinical Gastroenterology, 30(1), 3–15. https://doi.org/10.1016/j.bpg.2016.02.001

Dahiya, D., & Nigam, P. S. (2023). Antibiotic-Therapy-Induced Gut Dysbiosis Affecting Gut Microbiota—Brain Axis and Cognition: Restoration by Intake of Probiotics and Synbiotics. International Journal of Molecular Sciences, 24(4), 3074. https://doi.org/10.3390/ijms24043074

Éliás, A. J., Barna, V., Patoni, C., Demeter, D., Veres, D. S., Bunduc, S., Erőss, B., Hegyi, P., Földvári-Nagy, L., & Lenti, K. (2023). Probiotic supplementation during antibiotic treatment is unjustified in maintaining the gut microbiome diversity: A systematic review and meta-analysis. BMC Medicine, 21(1), 262. https://doi.org/10.1186/s12916-023-02961-0

Ferenc, K., Sokal-Dembowska, A., Helma, K., Motyka, E., Jarmakiewicz-Czaja, S., & Filip, R. (2024). Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics. International Journal of Molecular Sciences, 25(2), 1228. https://doi.org/10.3390/ijms25021228

Hong, M., Lan, T., Li, Q., Li, B., Yuan, Y., Xu, F., & Wang, W. (2023). A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines. Gut Microbes, 15(1), 2233146. https://doi.org/10.1080/19490976.2023.2233146

Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., & Chen, Z.-S. (2022). Microbiota in health and diseases. Signal Transduction and Targeted Therapy, 7(1), 135. https://doi.org/10.1038/s41392-022-00974-4

Kothari, D., Patel, S., & Kim, S.-K. (2019). Probiotic supplements might not be universally effective and safe: A review. Biomedicine & Pharmacotherapy, 111, 537–547. https://doi.org/10.1016/j.biopha.2018.12.104

Ma, T., Shen, X., Shi, X., Sakandar, H. A., Quan, K., Li, Y., Jin, H., Kwok, L.-Y., Zhang, H., & Sun, Z. (2023). Targeting gut microbiota and metabolism as the major probiotic mechanism—An evidence-based review. Trends in Food Science & Technology, 138, 178–198. https://doi.org/10.1016/j.tifs.2023.06.013

Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024). The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties. Microorganisms, 12(2), 234. https://doi.org/10.3390/microorganisms12020234

Nabavi-Rad, A., Sadeghi, A., Asadzadeh Aghdaei, H., Yadegar, A., Smith, S. M., & Zali, M. R. (2022). The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management. Gut Microbes, 14(1), 2108655. https://doi.org/10.1080/19490976.2022.2108655

Puig-Castellví, F., Pacheco-Tapia, R., Deslande, M., Jia, M., Andrikopoulos, P., Chechi, K., Bonnefond, A., Froguel, P., & Dumas, M.-E. (2023). Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications. TrAC Trends in Analytical Chemistry, 167, 117248. https://doi.org/10.1016/j.trac.2023.117248

Purdel, C., Ungurianu, A., Adam-Dima, I., & Margină, D. (2023). Exploring the potential impact of probiotic use on drug metabolism and efficacy. Biomedicine & Pharmacotherapy, 161, 114468. https://doi.org/10.1016/j.biopha.2023.114468

Rabetafika, H. N., Razafindralambo, A., Ebenso, B., & Razafindralambo, H. L. (2023). Probiotics as Antibiotic Alternatives for Human and Animal Applications. Encyclopedia, 3(2), 561–581. https://doi.org/10.3390/encyclopedia3020040

Rajkumar, C., Wilks, M., Islam, J., Ali, K., Raftery, J., Davies, K. A., Timeyin, J., Cheek, E., Cohen, J., Wright, J., Natarajan, U., Nicholl, C., Dewhurst, G., Fonseka, M., Slovick, D., Maskell, P., Mukherjee, S., Ali, K., Nari, R., … Aldulami, D. (2020). Do probiotics prevent antibiotic-associated diarrhea? Results of a multicentre randomized placebo-controlled trial. Journal of Hospital Infection, 105(2), 280–288. https://doi.org/10.1016/j.jhin.2020.01.018

Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G., Gasbarrini, A., & Mele, M. (2019). What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7(1), 14. https://doi.org/10.3390/microorganisms7010014

Suez, J., Zmora, N., & Elinav, E. (2020). Probiotics in the next-generation sequencing era. Gut Microbes, 11(1), 77–93. https://doi.org/10.1080/19490976.2019.1586039

Zhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L. (2023). Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review. Biomedicine & Pharmacotherapy, 164, 114985. https://doi.org/10.1016/j.biopha.2023.114985

Zheng, D., Liwinski, T., & Elinav, E. (2020). Interaction between microbiota and immunity in health and disease. Cell Research, 30(6), 492–506. https://doi.org/10.1038/s41422-020-0332-7

Downloads

Published

2024-05-30

How to Cite

Dey, S., & Sreejita Das. (2024). The Impact of Probiotics Co-administration with Antibiotics on Health. RADINKA JOURNAL OF HEALTH SCIENCE, 1(4), 123–130. https://doi.org/10.56778/rjhs.v1i4.237

Issue

Vol. 1 No. 4 (2024): Radinka Journal of Health Science (RJHS)

Section

A Literature Review

License

Copyright (c) 2024 RADINKA JOURNAL OF HEALTH SCIENCE

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

<meta name="google-site-verification" content="qBtkk8rnBm0ZRgy_14UYrahahLnkC844dKsDOFjzrn4" />